Following their story about gastric bypass and its impact gut microbiota and metabolic parameters, AP-HP, ICAN and INRA scientists continued to bring new discovers about the crosstalk between the gut microbiota and the host adipocytes. Variations of gut microbiota after gastric bypass were associated with changes in white adipose tissue gene expression. Those results may stimulate deeper investigation about relation between gut microbiota and adipocytes during weight loss.